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Trial for a vaccine

Sometimes it is not possible or desirable to conduct a trial for a vaccine. Following stringent processes by manufacturers and clinical trials, an evaluation can only be conducted as a modelling exercise. Consider the investigation in to the cost effectiveness of including boys in a human papillomavirus vaccination programme.

Kim JJ and Golding SJ. 2009. Cost effectiveness analysis of including boys in a human papillomavirus vaccination programme in the United States.BMJ, 339:b3884 [CAM628 Library Reading List]

1. What models did the team use?
2. What strategies were dominated in the cost-effectiveness analysis?
3. How did the authors investigate any uncertainty surrounding their model parameters?