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Jessica has used Nurofen Gel to ease her aching muscles. Discuss the benefits of this route of administration over an oral capsule in providing a higher bioavailability of the drug. (4 marks)

Discuss the importance of the half-life of a drug. What is the estimated half-life of ibuprofen (the active ingredient in Nurofen gel)? Using this estimate, calculate the amount of time it would take to achieve steady-state concentration and explain the importance of achieving steady state. (3 marks)