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Autophagy in atherosclerosis

In atherosclerosis Mechanical stretching (laminar, high, low magnitude and disturbed flow) and and its induce ROS responsible for Low Density Lipoprotein (LDL) oxidation. what are the mechanism involve in regulating the defective and effective autophagy under oxidized LDL and mechanical stretching.
How autophagy effective in advance atherosclerotic plaque.
How we can prevent the advance atherosclerosis plaque rapturing by modulating the autophagy?